产品详情

  • 产品名称：Human FUS (Fusion) Sandwich ELISA Kit Ready-To-Use (STJE0015385)

  • 产品型号：STJE0015385
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human FUS (Fusion) Sandwich ELISA Kit Ready-To-Use (STJE0015385)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.057ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This FUS Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: FUS
Gene ID: 2521
Uniprot ID: FUS_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Ubiquitous.
Post Translational Modifications Arg-216 and Arg-218 are dimethylated, probably to asymmetric dimethylarginine. Phosphorylated in its N-terminal serine residues upon induced DNA damage. ATM and DNA-PK are able to phosphorylate FUS N-terminal region.
Function DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing. Binds also its own pre-mRNA and autoregulates its expression.this autoregulation mechanism is mediated by non-sense-mediated decay. Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair. In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis.
Protein Name Rna-Binding Protein Fus
75 Kda Dna-Pairing Protein
Oncogene Fus
Oncogene Tls
Pomp75
Translocated In Liposarcoma Protein
Database Links Reactome: R-HSA-72163
Reactome: R-HSA-72203
Cellular Localisation Nucleus
Displays A Punctate Pattern Inside The Nucleus And Is Excluded From Nucleoli
Alternative ELISA Names Rna-Binding Protein Fus ELISA kit
75 Kda Dna-Pairing Protein ELISA kit
Oncogene Fus ELISA kit
Oncogene Tls ELISA kit
Pomp75 ELISA kit
Translocated In Liposarcoma Protein ELISA kit
FUS ELISA kit
TLS ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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