产品详情
简单介绍:
Anti-BMPR1A antibody (460-510) {Biotin} (STJ500280)
详情介绍:
Host: | Rabbit |
Applications: | ELISA/IHC/IP/WB |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-BMPR1A (460-510) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Biotin |
Isotype: | IgG |
Purification: | Affinity Purified |
Concentration: | 0.5 µg/µl |
Dilution Range: | WB: 1:500 ELISA: 1:10, 000 IP: 1:150 IHC: 1:50-1:100 |
Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Gene Symbol: | BMPR1A |
Gene ID: | 657 |
Uniprot ID: | BMR1A_HUMAN |
Immunogen Region: | 460-510 |
Immunogen: | Synthetic peptide taken within amino acid region 460-510 on human Bone morphogenetic protein receptor type-1A. |
Tissue Specificity | Highly expressed in skeletal muscle. |
Post Translational Modifications | Glycosylated. |
Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2. |
Protein Name | Bone Morphogenetic Protein Receptor Type-1a Bmp Type-1a Receptor Bmpr-1a Activin Receptor-Like Kinase 3 Alk-3 Serine/Threonine-Protein Kinase Receptor R5 Skr5 Cd Antigen Cd292 |
Database Links | Reactome: R-HSA-201451 |
Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Cell Surface |
Alternative Antibody Names | Anti-Bone Morphogenetic Protein Receptor Type-1a antibody Anti-Bmp Type-1a Receptor antibody Anti-Bmpr-1a antibody Anti-Activin Receptor-Like Kinase 3 antibody Anti-Alk-3 antibody Anti-Serine/Threonine-Protein Kinase Receptor R5 antibody Anti-Skr5 antibody Anti-Cd Antigen Cd292 antibody Anti-BMPR1A antibody Anti-ACVRLK3 antibody Anti-ALK3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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