产品详情

  • 产品名称：SESN1 Positive Control for STJ502954 peptide (STJ505132)

  • 产品型号：STJ505132-5
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
SESN1 Positive Control for STJ502954 peptide (STJ505132)
详情介绍：
Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: SESN1 Positive Control for STJ502954 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: SESN1
Gene ID: 27244
Uniprot ID: SESN1_HUMAN
Specificity: This is positive control is recommended for use in combination with SESN1 antibody STJ502954.
Tissue Specificity Widely expressed.
Function Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed.
Peptide Name Sestrin-1
P53-Regulated Protein Pa26
Database Links Reactome: R-HSA-5628897
Reactome: R-HSA-9639288
Reactome: R-HSA-9755511
Cellular Localisation Nucleus
Cytoplasm
Alternative Peptide Names Sestrin-1 protein
P53-Regulated Protein Pa26 protein
SESN1 protein
PA26 protein
SEST1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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