产品详情

  • 产品名称：Anti-ARNT antibody (499-789) [S1MR] (STJ11101681)

  • 产品型号：STJ11101681
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ARNT antibody (499-789) [S1MR] (STJ11101681)
详情介绍：
Host: Rabbit
Applications: WB/IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-HIF1 Beta/ARNT (499-789) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: S1MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ARNT
Gene ID: 405
Uniprot ID: ARNT_HUMAN
Immunogen Region: 499-789
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 499-789 of human HIF-1 beta (P27540).
Immunogen Sequence: LAPRQQQQQTELDMVPGRDG LASYNHSQVVQPVTTTGPEH SKPLEKSDGLFAQDRDPRFS EIYHNINADQSKGISSSTVP ATQQLFSQGNTFPPTPRPAE NFRNSGLAPPVTIVQPSASA GQMLAQISRHSNPTQGATPT WTPTTRSGFSAQQVATQATA KTRTSQFGVGSFQTPSSFSS MSLPGAPTASPGAAAYPSLT NRGSNFAPETGQTAGQFQTR TAEGVGVWPQWQGQQPHHR
Function Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (Probable). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription.
Protein Name Aryl Hydrocarbon Receptor Nuclear Translocator
Arnt Protein
Class E Basic Helix-Loop-Helix Protein 2
Bhlhe2
Dioxin Receptor - Nuclear Translocator
Hypoxia-Inducible Factor 1-Beta
Hif-1-Beta
Hif1-Beta
Database Links Reactome: R-HSA-1234158
Reactome: R-HSA-1989781
Reactome: R-HSA-211945
Reactome: R-HSA-211976
Reactome: R-HSA-211981
Reactome: R-HSA-8937144
Reactome: R-HSA-9768919
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Aryl Hydrocarbon Receptor Nuclear Translocator antibody
Anti-Arnt Protein antibody
Anti-Class E Basic Helix-Loop-Helix Protein 2 antibody
Anti-Bhlhe2 antibody
Anti-Dioxin Receptor - Nuclear Translocator antibody
Anti-Hypoxia-Inducible Factor 1-Beta antibody
Anti-Hif-1-Beta antibody
Anti-Hif1-Beta antibody
Anti-ARNT antibody
Anti-BHLHE2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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