产品详情

  • 产品名称：Human CFLAR (CASP8 And FADD Like Apoptosis Regulator) Sandwich ELISA Kit (STJE0007904)

  • 产品型号：STJE0007904
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human CFLAR (CASP8 And FADD Like Apoptosis Regulator) Sandwich ELISA Kit (STJE0007904)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.061ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This CFLAR Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: CFLAR
Gene ID: 8837
Uniprot ID: CFLAR_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.
Post Translational Modifications Proteolytically processed by CASP8 generating subunit p43 and p12.
Function Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
Protein Name Casp8 And Fadd-Like Apoptosis Regulator
Caspase Homolog
Cash
Caspase-Eight-Related Protein
Casper
Caspase-Like Apoptosis Regulatory Protein
Clarp
Cellular Flice-Like Inhibitory Protein
C-Flip
Fadd-Like Antiapoptotic Molecule 1
Flame-1
Inhibitor Of Flice
I-Flice
Mach-Related Inducer Of Toxicity
Mrit
Usurpin Cleaved Into - Casp8 And Fadd-Like Apoptosis Regulator Subunit P43 - Casp8 And Fadd-Like Apoptosis Regulator Subunit P12
Database Links Reactome: R-HSA-3371378 O15519-1
Reactome: R-HSA-5213460
Reactome: R-HSA-5218900
Reactome: R-HSA-5357905 O15519-1
Reactome: R-HSA-69416 O15519-2
Reactome: R-HSA-75158
Cellular Localisation
Alternative ELISA Names Casp8 And Fadd-Like Apoptosis Regulator ELISA kit
Caspase Homolog ELISA kit
Cash ELISA kit
Caspase-Eight-Related Protein ELISA kit
Casper ELISA kit
Caspase-Like Apoptosis Regulatory Protein ELISA kit
Clarp ELISA kit
Cellular Flice-Like Inhibitory Protein ELISA kit
C-Flip ELISA kit
Fadd-Like Antiapoptotic Molecule 1 ELISA kit
Flame-1 ELISA kit
Inhibitor Of Flice ELISA kit
I-Flice ELISA kit
Mach-Related Inducer Of Toxicity ELISA kit
Mrit ELISA kit
Usurpin Cleaved Into - Casp8 And Fadd-Like Apoptosis Regulator Subunit P43 - Casp8 And Fadd-Like Apoptosis Regulator Subunit P12 ELISA kit
CFLAR ELISA kit
CASH ELISA kit
CASP8AP1 ELISA kit
CLARP ELISA kit
MRIT ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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