产品详情

  • 产品名称：Anti-BCKDHA antibody (276-445) (STJ11104430)

  • 产品型号：STJ11104430
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-BCKDHA antibody (276-445) (STJ11104430)
详情介绍：
Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-2-Oxoisovalerate Dehydrogenase Subunit Alpha-Mitochondrial (276-445) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: BCKDHA
Gene ID: 593
Uniprot ID: ODBA_HUMAN
Immunogen Region: 276-445
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 276-445 of human BCKDHA (NP_000700.1).
Immunogen Sequence: SEQYRGDGIAARGPGYGIMS IRVDGNDVFAVYNATKEARR RAVAENQPFLIEAMTYRIGH HSTSDDSSAYRSVDEVNYWD KQDHPISRLRHYLLSQGWWD EEQEKAWRKQSRRKVMEAFE QAERKPKPNPNLLFSDVYQE MPAQLRKQQESLARHLQTYG EHYPLDHFDK
Function Together with BCKDHB forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction.
Protein Name 2-Oxoisovalerate Dehydrogenase Subunit Alpha - Mitochondrial
Branched-Chain Alpha-Keto Acid Dehydrogenase E1 Component Alpha Chain
Bckde1a
Bckdh E1-Alpha
Database Links Reactome: R-HSA-389661
Reactome: R-HSA-70895
Cellular Localisation Mitochondrion Matrix
Alternative Antibody Names Anti-2-Oxoisovalerate Dehydrogenase Subunit Alpha - Mitochondrial antibody
Anti-Branched-Chain Alpha-Keto Acid Dehydrogenase E1 Component Alpha Chain antibody
Anti-Bckde1a antibody
Anti-Bckdh E1-Alpha antibody
Anti-BCKDHA antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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