产品详情

  • 产品名称：Human ENPP1 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 1) Sandwich ELISA Kit Ready-To-Use (STJE0015028)

  • 产品型号：STJE0015028
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human ENPP1 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 1) Sandwich ELISA Kit Ready-To-Use (STJE0015028)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.062ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This ENPP1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: ENPP1
Gene ID: 5167
Uniprot ID: ENPP1_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Expressed in plasma cells and also in a number of non-lymphoid tissues, including the distal convoluted tubule of the kidney, chondrocytes and epididymis. Expressed in melanocytes but not in keratinocytes.
Post Translational Modifications Autophosphorylated as part of the catalytic cycle of phosphodiesterase/pyrophosphatase activity. N-glycosylated. The secreted form is produced through cleavage at Lys-103 by intracellular processing.
Function Nucleotide pyrophosphatase that generates diphosphate (PPi) and functions in bone mineralization and soft tissue calcification by regulating pyrophosphate levels. PPi inhibits bone mineralization and soft tissue calcification by binding to nascent hydroxyapatite crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP and UTP to their corresponding monophosphates with release of pyrophosphate, as well as diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling.it is however unclear whether hedgehog inhibition is direct or indirect. Appears to modulate insulin sensitivity and function. Also involved in melanogenesis. Also able to hydrolyze 2',3'-cGAMP (cyclic GMP-AMP), a second messenger that activates TMEM173/STING and triggers type-I interferon production. 2',3'-cGAMP degradation takes place in the lumen or extracellular space, and not in the cytosol where it is produced.the role of 2',3'-cGAMP hydrolysis is therefore unclear. Not able to hydrolyze the 2',3'-cGAMP linkage isomer 3'-3'-cGAMP.
Protein Name Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 1
E-Npp 1
Membrane Component Chromosome 6 Surface Marker 1
Phosphodiesterase I/Nucleotide Pyrophosphatase 1
Plasma-Cell Membrane Glycoprotein Pc-1 Cleaved Into - Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 1 - Secreted Form Includes - Alkaline Phosphodiesterase I - Nucleotide Pyrophosphatase
Nppase
Nucleotide Diphosphatase
Database Links Reactome: R-HSA-196843
Reactome: R-HSA-199220
Cellular Localisation Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 1: Cell Membrane
Single-Pass Type Ii Membrane Protein
Basolateral Cell Membrane
Targeted To The Basolateral Membrane In Polarized Epithelial Cells And In Hepatocytes
And To Matrix Vesicles In Osteoblasts
In Bile Duct Cells And Cancer Cells
Located To The Apical Cytoplasmic Side
Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 1
Secreted Form: Secreted
Secreted Following Proteolytic Cleavage
Alternative ELISA Names Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 1 ELISA kit
E-Npp 1 ELISA kit
Membrane Component Chromosome 6 Surface Marker 1 ELISA kit
Phosphodiesterase I/Nucleotide Pyrophosphatase 1 ELISA kit
Plasma-Cell Membrane Glycoprotein Pc-1 Cleaved Into - Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 1 - Secreted Form Includes - Alkaline Phosphodiesterase I - Nucleotide Pyrophosphatase ELISA kit
Nppase ELISA kit
Nucleotide Diphosphatase ELISA kit
ENPP1 ELISA kit
M6S1 ELISA kit
NPPS ELISA kit
PC1 ELISA kit
PDNP1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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