产品详情

  • 产品名称：Anti-BARD1 antibody (1-50 aa) (STJ91817)

  • 产品型号：STJ91817
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-BARD1 antibody (1-50 aa) (STJ91817)
详情介绍：
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-BRCA1-associated RING domain protein 1 (1-50 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:5000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: BARD1
Gene ID: 580
Uniprot ID: BARD1_HUMAN
Immunogen Region: 1-50 aa
Specificity: BARD1 Polyclonal Antibody detects endogenous levels of BARD1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human BARD1 at the amino acid range 1-50
Function E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.
Protein Name Brca1-Associated Ring Domain Protein 1
Bard-1
Ring-Type E3 Ubiquitin Transferase Bard1
Database Links Reactome: R-HSA-5685938
Reactome: R-HSA-5685942
Reactome: R-HSA-5689603
Reactome: R-HSA-5689901
Reactome: R-HSA-5693554
Reactome: R-HSA-5693565
Reactome: R-HSA-5693568
Reactome: R-HSA-5693571
Reactome: R-HSA-5693579
Reactome: R-HSA-5693607
Reactome: R-HSA-5693616
Reactome: R-HSA-6804756
Reactome: R-HSA-69473
Reactome: R-HSA-9663199
Reactome: R-HSA-9699150
Reactome: R-HSA-9701192
Reactome: R-HSA-9704331
Reactome: R-HSA-9704646
Reactome: R-HSA-9709570
Reactome: R-HSA-9709603
Cellular Localisation Nucleus
During S Phase Of The Cell Cycle
Colocalizes With Brca1 Into Discrete Subnuclear Foci
Can Translocate To The Cytoplasm
Localizes At Sites Of Dna Damage At Double-Strand Breaks (Dsbs)
Recruitment To Dna Damage Sites Is Mediated By The Brca1-A Complex
Alternative Antibody Names Anti-Brca1-Associated Ring Domain Protein 1 antibody
Anti-Bard-1 antibody
Anti-Ring-Type E3 Ubiquitin Transferase Bard1 antibody
Anti-BARD1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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