产品详情

  • 产品名称：Anti-APOBEC3G/ARP9 antibody (Internal) (STJ73290)

  • 产品型号：STJ73290-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-APOBEC3G/ARP9 antibody (Internal) (STJ73290)
详情介绍：
Host: Goat
Applications: Pep-ELISA/IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-APOBEC3G/ARP9 (Internal) is suitable for use in ELISA and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: IHC-Recommended concentration, 1-2µg/ml
ELISA-antibody detection limit dilution 1:64000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: APOBEC3G
Gene ID: 60489
Uniprot ID: ABC3G_HUMAN
Immunogen Region: Internal
Accession Number: NP_068594.1
Immunogen Sequence: SKWRKLHRDQE
Post Translational Modifications Ubiquitinated in the presence of HIV-1 Vif. Association with Vif targets the protein for proteolysis by the ubiquitin-dependent proteasome pathway. Phosphorylation at Thr-32 reduces its binding to HIV-1 Vif and subsequent ubiquitination and degradation thus promoting its antiviral activity.
Function DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity against Vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV). May inhibit the mobility of LTR and non-LTR retrotransposons.
Protein Name Dna Dc->Du-Editing Enzyme Apobec-3g
Apobec-Related Cytidine Deaminase
Apobec-Related Protein
Arcd
Apobec-Related Protein 9
Arp-9
Cem-15
Cem15
Deoxycytidine Deaminase
A3g
Database Links Reactome: R-HSA-180585
Reactome: R-HSA-180689
Cellular Localisation Cytoplasm
Nucleus
P-Body
Mainly Cytoplasmic
Small Amount Are Found In The Nucleus
During Hiv-1 Infection
Virion-Encapsidated In Absence Of Hiv-1 Vif
Alternative Antibody Names Anti-Dna Dc->Du-Editing Enzyme Apobec-3g antibody
Anti-Apobec-Related Cytidine Deaminase antibody
Anti-Apobec-Related Protein antibody
Anti-Arcd antibody
Anti-Apobec-Related Protein 9 antibody
Anti-Arp-9 antibody
Anti-Cem-15 antibody
Anti-Cem15 antibody
Anti-Deoxycytidine Deaminase antibody
Anti-A3g antibody
Anti-APOBEC3G antibody
Anti-MDS019 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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