产品详情

  • 产品名称：Human DOCK3 (Dedicator Of Cytokinesis 3) Sandwich ELISA Kit Ready-To-Use (STJE0014864)

  • 产品型号：STJE0014864
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human DOCK3 (Dedicator Of Cytokinesis 3) Sandwich ELISA Kit Ready-To-Use (STJE0014864)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.053ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This DOCK3 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: DOCK3
Gene ID: 1795
Uniprot ID: DOCK3_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity In normal brains, it is localized in the neuropil, and occasionally in the pyramidal cells, while in Alzheimer disease brains, it is associated with neurofibrillary tangles.
Post Translational Modifications
Function Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors.
Protein Name Dedicator Of Cytokinesis Protein 3
Modifier Of Cell Adhesion
Presenilin-Binding Protein
Pbp
Database Links Reactome: R-HSA-9013149
Reactome: R-HSA-9013404
Reactome: R-HSA-9013408
Reactome: R-HSA-9032759
Reactome: R-HSA-983231
Cellular Localisation Cytoplasm
Alternative ELISA Names Dedicator Of Cytokinesis Protein 3 ELISA kit
Modifier Of Cell Adhesion ELISA kit
Presenilin-Binding Protein ELISA kit
Pbp ELISA kit
DOCK3 ELISA kit
KIAA0299 ELISA kit
MOCA ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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