产品详情

  • 产品名称：Human DNMT3B (DNA Methyltransferase 3B) Sandwich ELISA Kit Ready-To-Use (STJE0014862)

  • 产品型号：STJE0014862
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human DNMT3B (DNA Methyltransferase 3B) Sandwich ELISA Kit Ready-To-Use (STJE0014862)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.054ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This DNMT3B Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: DNMT3B
Gene ID: 1789
Uniprot ID: DNM3B_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Ubiquitous.highly expressed in fetal liver, heart, kidney, placenta, and at lower levels in spleen, colon, brain, liver, small intestine, lung, peripheral blood mononuclear cells, and skeletal muscle. Isoform 1 is expressed in all tissues except brain, skeletal muscle and PBMC, 3 is ubiquitous, 4 is expressed in all tissues except brain, skeletal muscle, lung and prostate and 5 is detectable only in testis and at very low level in brain and prostate.
Post Translational Modifications Sumoylated. Citrullinated by PADI4.
Function Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Functions as a transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells.
Protein Name Dna
Cytosine-5-Methyltransferase 3b
Dnmt3b
Dna Methyltransferase Hsaiiib
Dna Mtase Hsaiiib
M.hsaiiib
Database Links Reactome: R-HSA-212300
Reactome: R-HSA-427413
Reactome: R-HSA-4655427
Reactome: R-HSA-5334118
Reactome: R-HSA-9710421
Cellular Localisation Nucleus
Alternative ELISA Names Dna ELISA kit
Cytosine-5-Methyltransferase 3b ELISA kit
Dnmt3b ELISA kit
Dna Methyltransferase Hsaiiib ELISA kit
Dna Mtase Hsaiiib ELISA kit
M.hsaiiib ELISA kit
DNMT3B ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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