产品详情

  • 产品名称：Anti-AZIN2 antibody (STJA0009740)

  • 产品型号：STJA0009740
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-AZIN2 antibody (STJA0009740)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-antizyme inhibitor 2 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: AZIN2
Gene ID: 113451
Uniprot ID: AZIN2_HUMAN
Specificity: This antibody detects endogenous levels of ADC at Human, Mouse
Immunogen: Synthesized peptide derived from human ADC
Post Translational Modifications Ubiquitinated, leading to its proteasomal degradation.a process that is reduced in presence of antizymes. May also be degraded through the lysosomal degradative pathway in a proteasomal-independent manner.
Function Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production. Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking.
Protein Name Antizyme Inhibitor 2
Azi2
Arginine Decarboxylase
Adc
Argdc
Ornithine Decarboxylase-Like Protein
Odc-Like Protein
Ornithine Decarboxylase Paralog
Odc-P
Database Links Reactome: R-HSA-351143
Cellular Localisation Nucleus
Cytoplasm
Perinuclear Region
Membrane
Cytoplasmic Vesicle
Endoplasmic Reticulum-Golgi Intermediate Compartment
Golgi Apparatus
Cis-Golgi Network
Trans-Golgi Network
Cytoplasmic Granule
Cell Projection
Axon
Dendrite
Perikaryon
Colocalizes With Kdel Receptors In Er-Golgi Intermediate Compartment (Ergic)
Translocates From The Ergic Structure To The Cytoplasm In An Antizyme-Dependent Manner
Localizes With Vesicle-Associated Membrane Protein Vamp8 In The Vicinity Of The Plasma Membrane Within Serotonin-Containing Secretory Granules
Detected As Vesicle-Like Pattern In Neurite Outgrowths
Localizes To The Vesicular Compartments Of The Secretory Pathway
Predominantly In The Trans-Golgi Network (Tgn)
Alternative Antibody Names Anti-Antizyme Inhibitor 2 antibody
Anti-Azi2 antibody
Anti-Arginine Decarboxylase antibody
Anti-Adc antibody
Anti-Argdc antibody
Anti-Ornithine Decarboxylase-Like Protein antibody
Anti-Odc-Like Protein antibody
Anti-Ornithine Decarboxylase Paralog antibody
Anti-Odc-P antibody
Anti-AZIN2 antibody
Anti-ADC antibody
Anti-KIAA1945 antibody
Anti-ODCP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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