产品详情

  • 产品名称：Human DMT1 (Divalent Metal Transporter 1) Sandwich ELISA Kit (STJE0008466)

  • 产品型号：STJE0008466
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human DMT1 (Divalent Metal Transporter 1) Sandwich ELISA Kit (STJE0008466)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.112ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This DMT1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: SLC11A2
Gene ID: 4891
Uniprot ID: NRAM2_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Ubiquitously expressed. Expressed in erythroid progenitors.
Post Translational Modifications Ubiquitinated by WWP2. N-glycosylated.
Function Proton-coupled metal ion symporter operating with a proton to metal ion stoichiometry of 1:1. Selectively transports various divalent metal cations, in decreasing affinity: Cd(2+) > Fe(2+) > Co(2+), Mn(2+) >> Zn(2+), Ni(2+), VO(2+). Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe(2+) and TF-associated endosomal Fe(2+) transport in erythroid precursors and other cells. Enables Fe(2+) and Mn(2+) ion entry into mitochondria, and is thus expected to promote mitochondrial heme synthesis, iron-sulfur cluster biogenesis and antioxidant defense. Can mediate uncoupled fluxes of either protons or metal ions.
Protein Name Natural Resistance-Associated Macrophage Protein 2
Nramp 2
Divalent Cation Transporter 1
Divalent Metal Transporter 1
Dmt-1
Solute Carrier Family 11 Member 2
Database Links Reactome: R-HSA-425410
Reactome: R-HSA-5619048
Reactome: R-HSA-917937
Cellular Localisation Isoform 1: Early Endosome Membrane
Multi-Pass Membrane Protein
Apical Cell Membrane
Predominantly Localizes In Early Endosomes That Underlie The Apical Membrane Of Polarized Epithelia
Isoform 2: Late Endosome Membrane
Lysosome Membrane
Cell Membrane
Extracellular Vesicle Membrane
Isoform 3: Cell Membrane
Mitochondrion Outer Membrane
Golgi Apparatus
Trans-Golgi Network Membrane
Recycling Endosome Membrane
Alternative ELISA Names Natural Resistance-Associated Macrophage Protein 2 ELISA kit
Nramp 2 ELISA kit
Divalent Cation Transporter 1 ELISA kit
Divalent Metal Transporter 1 ELISA kit
Dmt-1 ELISA kit
Solute Carrier Family 11 Member 2 ELISA kit
SLC11A2 ELISA kit
DCT1 ELISA kit
DMT1 ELISA kit
NRAMP2 ELISA kit
OK ELISA kit
SW-cl.20 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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