产品详情

  • 产品名称：Human CYP27A1 (Cytochrome P450 27A1) Sandwich ELISA Kit Ready-To-Use (STJE0014690)

  • 产品型号：STJE0014690
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human CYP27A1 (Cytochrome P450 27A1) Sandwich ELISA Kit Ready-To-Use (STJE0014690)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.061ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This CYP27A1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: CYP27A1
Gene ID: 1593
Uniprot ID: CP27A_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Expressed in the neural retina and underlying retinal pigment epithelium (at protein level). Expressed in the gray and white matter of cerebellum (at protein level).
Post Translational Modifications
Function Cytochrome P450 monooxygenase that catalyzes regio- and stereospecific hydroxylation of cholesterol and its derivatives. Hydroxylates (with R stereochemistry) the terminal methyl group of cholesterol side-chain in a three step reaction to yield at first a C26 alcohol, then a C26 aldehyde and finally a C26 acid. Regulates cholesterol homeostasis by catalyzing the conversion of excess cholesterol to bile acids via both the 'neutral' (classic) and the 'acid' (alternative) pathways. May also regulate cholesterol homeostasis via generation of active oxysterols, which act as ligands for NR1H2 and NR1H3 nuclear receptors, modulating the transcription of genes involved in lipid metabolism. Plays a role in cholestanol metabolism in the cerebellum. Similarly to cholesterol, hydroxylates cholestanol and may facilitate sterol diffusion through the blood-brain barrier to the systemic circulation for further degradation. Also hydroxylates retinal 7-ketocholesterol, a noxious oxysterol with pro-inflammatory and pro-apoptotic effects, and may play a role in its elimination from the retinal pigment epithelium. May play a redundant role in vitamin D biosesynthesis. Catalyzes 25-hydroxylation of vitamin D3 that is required for its conversion to a functionally active form.
Protein Name Sterol 26-Hydroxylase - Mitochondrial
5-Beta-Cholestane-3-Alpha -7-Alpha -12-Alpha-Triol 26-Hydroxylase
Cytochrome P-450c27/25
Cytochrome P450 27
Sterol 27-Hydroxylase
Vitamin D(3 25-Hydroxylase
Database Links Reactome: R-HSA-193368
Reactome: R-HSA-193775
Reactome: R-HSA-193807
Reactome: R-HSA-211976
Reactome: R-HSA-5578996
Cellular Localisation Mitochondrion Inner Membrane
Peripheral Membrane Protein
Post-Translationally Targeted To Mitochondria
All Three Of The Receptor Proteins In The Tom Complex
Tomm70
Tomm20 And Tomm22 Are Required For The Translocations Across The Mitochondrial Outer Membrane
After Translocations Into The Matrix
Associates With The Inner Membrane As A Membrane Extrinsic Protein
Alternative ELISA Names Sterol 26-Hydroxylase - Mitochondrial ELISA kit
5-Beta-Cholestane-3-Alpha -7-Alpha -12-Alpha-Triol 26-Hydroxylase ELISA kit
Cytochrome P-450c27/25 ELISA kit
Cytochrome P450 27 ELISA kit
Sterol 27-Hydroxylase ELISA kit
Vitamin D(3 25-Hydroxylase ELISA kit
CYP27A1 ELISA kit
CYP27 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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