产品详情

  • 产品名称：Anti-ATG12 antibody (41-140) [S9MR] (STJ11101729)

  • 产品型号：STJ11101729
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ATG12 antibody (41-140) [S9MR] (STJ11101729)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-ATG12 (41-140) is suitable for use in Western Blot research applications.
Clonality: Monoclonal
Clone ID: S9MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ATG12
Gene ID: 9140
Uniprot ID: ATG12_HUMAN
Immunogen Region: 41-140
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 41-140 of human Apg12 (O94817).
Immunogen Sequence: SPGTEEPAGDTKKKIDILLK AVGDTPIMKTKKWAVERTRT IQGLIDFIKKFLKLVASEQL FIYVNQSFAPSPDQEVGTLY ECFGSDGKLVLHYCKSQAWG
Tissue Specificity Ubiquitous.
Post Translational Modifications Acetylated by EP300.
Function Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. (Microbial infection) May act as a proviral factor. In association with ATG5, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection. Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for the initiation of HCV replication, but not required once infection is established.
Protein Name Ubiquitin-Like Protein Atg12
Autophagy-Related Protein 12
Apg12-Like
Database Links Reactome: R-HSA-1632852
Reactome: R-HSA-5205685
Reactome: R-HSA-8934903
Reactome: R-HSA-936440
Cellular Localisation Cytoplasm
Preautophagosomal Structure Membrane
Peripheral Membrane Protein
Tecpr1 Recruits The Atg12-Atg5 Conjugate To The Autolysosomal Membrane
Alternative Antibody Names Anti-Ubiquitin-Like Protein Atg12 antibody
Anti-Autophagy-Related Protein 12 antibody
Anti-Apg12-Like antibody
Anti-ATG12 antibody
Anti-APG12 antibody
Anti-APG12L antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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