产品详情

  • 产品名称：Syncytin 1 Blocking Peptide peptide (STJ505530)

  • 产品型号：STJ505530-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Syncytin 1 Blocking Peptide peptide (STJ505530)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Syncytin 1 Blocking Peptide is synthetically produced from the 480-538 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: ERVW-1
Gene ID: 30816
Uniprot ID: SYCY1_HUMAN
Immunogen Region: 480-538
Immunogen: Synthetic peptide taken within amino acid region 480-538 on human Syncytin-1 protein.
Tissue Specificity Expressed at higher level in placental syncytiotrophoblast. Expressed at intermediate level in testis. Seems also to be found at low level in adrenal tissue, bone marrow, breast, colon, kidney, ovary, prostate, skin, spleen, thymus, thyroid, brain and trachea. Both mRNA and protein levels are significantly increased in the brain of individuals with multiple sclerosis, particularly in astrocytes and microglia.
Post Translational Modifications Specific enzymatic cleavages in vivo yield mature proteins. Envelope glycoproteins are synthesized as an inactive precursor that is heavily N-glycosylated and processed likely by furin in the Golgi to yield the mature SU and TM proteins. The cleavage site between SU and TM requires the minimal sequence KR-X-KR-R. The intracytoplasmic tail cleavage by the viral protease that is required for the fusiogenic activity of some retroviruses envelope proteins seems to have been lost during evolution. The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion.
Function This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein (SU) mediates receptor recognition, while the transmembrane protein (TM) acts as a class I viral fusion protein. The protein may have at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of membranes.
Peptide Name Syncytin-1
Endogenous Retrovirus Group W Member 1
Env-W
Envelope Polyprotein Gpr73
Enverin
Herv-7q Envelope Protein
Herv-W Envelope Protein
Herv-W_7q21.2 Provirus Ancestral Env Polyprotein
Syncytin Cleaved Into - Surface Protein
Su
Gp50 - Transmembrane Protein
Tm
Gp24
Cellular Localisation Surface Protein: Cell Membrane
Peripheral Membrane Protein
The Surface Protein Is Not Anchored To The Membrane
But Localizes To The Extracellular Surface Through Its Binding To Tm
Transmembrane Protein: Cell Membrane
Single-Pass Type I Membrane Protein
Syncytin-1: Virion
Alternative Peptide Names Syncytin-1 protein
Endogenous Retrovirus Group W Member 1 protein
Env-W protein
Envelope Polyprotein Gpr73 protein
Enverin protein
Herv-7q Envelope Protein protein
Herv-W Envelope Protein protein
Herv-W_7q21.2 Provirus Ancestral Env Polyprotein
Syncytin Cleaved Into - Surface Protein protein
Su protein
Gp50 - Transmembrane Protein protein
Tm protein
Gp24 protein
ERVW-1 protein
ERVWE1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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