产品详情

  • 产品名称：Sodium/Hydrogen Exchanger 3 Blocking Peptide peptide (STJ504941)

  • 产品型号：STJ504941-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Sodium/Hydrogen Exchanger 3 Blocking Peptide peptide (STJ504941)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Sodium/Hydrogen Exchanger 3 Blocking Peptide is synthetically produced from the 790-835 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: SLC9A3
Gene ID: 6550
Uniprot ID: SL9A3_HUMAN
Immunogen Region: 790-835
Immunogen: Synthetic peptide taken within amino acid region 790-835 on Slc9A3 protein.
Post Translational Modifications Phosphorylated by PKA, which inhibits activity. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane. Phosphorylation at Ser-718 by CSNK2A1 regulates SLC9A3 activity through the formation of multiple signaling complexes.
Function Plasma membrane Na(+)/H(+) antiporter. Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis. Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation.
Peptide Name Sodium/Hydrogen Exchanger 3
Na(+/H(+ Exchanger 3
Nhe-3
Solute Carrier Family 9 Member 3
Database Links Reactome: R-HSA-425986
Cellular Localisation Apical Cell Membrane
Multi-Pass Membrane Protein
Cell Membrane
Recycling Endosome Membrane
Early Endosome Membrane
In Intestinal Epithelial Cells
Localizes To The Ileal Brush Border
Phosphorylation At Ser-663 By Sgk1 Is Associated With Increased Abundance At The Cell Membrane
Angiotensin-2 Enhances Apical Expression
Alternative Peptide Names Sodium/Hydrogen Exchanger 3 protein
Na(+/H(+ Exchanger 3 protein
Nhe-3 protein
Solute Carrier Family 9 Member 3 protein
SLC9A3 protein
NHE3 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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