产品详情

  • 产品名称：SLFN11 Blocking Peptide for STJ506360 peptide (STJ506362)

  • 产品型号：STJ506362-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
SLFN11 Blocking Peptide for STJ506360 peptide (STJ506362)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: SLFN11 Blocking Peptide for STJ506360 is synthetically produced from the 150-200 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: SLFN11
Gene ID: 91607
Uniprot ID: SLN11_HUMAN
Immunogen Region: 150-200
Specificity: This blocking peptide is recommended for use in combination with SLFN11 antibody, STJ506360
Tissue Specificity Exhibits a wider expression range in ovarian and colon adenocarcinoma than in their corresponding healthy tissues.
Function Inhibitor of DNA replication that promotes cell death in response to DNA damage. Acts as a guardian of the genome by killing cells with defective replication. Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death. Acts independently of ATR. Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis. Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner. Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides. The exact inhibition mechanism is unclear: may either sequester tRNAs, prevent their maturation via post-transcriptional processing or may accelerate their deacylation. Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA.
Peptide Name Schlafen Family Member 11
Cellular Localisation Nucleus
Chromosome
Recruited To Stressed Replication Forks Carrying Extended Rpa Filaments
Recruited To Dna Damage Sites Via Interaction With Rpa1
Alternative Peptide Names Schlafen Family Member 11 protein
SLFN11 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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