产品详情

  • 产品名称：Mouse NKG2D/CD314 protein (Recombinant) (N-hFc) (STJP002377)

  • 产品型号：STJP002377
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Mouse NKG2D/CD314 protein (Recombinant) (N-hFc) (STJP002377)
详情介绍：
Host: HEK293 cells
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse NKG2D/CD314-N-hFc protein was developed from hek293 cells and has a target region of N-hFc. For use in research applications.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Klrk1
Gene ID: 27007
Uniprot ID: NKG2D_MOUSE
Immunogen Region: Phe90-Val232
Immunogen: Recombinant Mouse NKG2D/CD314 Protein is expressed by HEK293 cells expression system. The target protein is expressed with sequence Phe90-Val232 of NKG2D/CD314 (Accession #NP_149069.1) fused with a hFc at the N-terminus
Function Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including RAET1A, RAET1B, RAET1C, RAET1D, RAET1E, H60 and MULT1.
Protein Name Nkg2-D Type Ii Integral Membrane Protein
Killer Cell Lectin-Like Receptor Subfamily K Member 1
Nk Cell Receptor D
Nkg2-D-Activating Nk Receptor
Cd Antigen Cd314
Database Links Reactome: R-MMU-198933
Reactome: -MMU-2424491
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Colocalized With Hcst And Tyrobp On The Cell Surface
Alternative Protein Names Nkg2-D Type Ii Integral Membrane Protein protein
Killer Cell Lectin-Like Receptor Subfamily K Member 1 protein
Nk Cell Receptor D protein
Nkg2-D-Activating Nk Receptor protein
Cd Antigen Cd314 protein
Klrk1 protein
Nkg2d protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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