产品详情

  • 产品名称：Anti-ASCC3 antibody (1-111) (STJ110267)

  • 产品型号：STJ110267
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ASCC3 antibody (1-111) (STJ110267)
详情介绍：
Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ASCC3 (1-111) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IF/ICC 1:50-1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ASCC3
Gene ID: 10973
Uniprot ID: ASCC3_HUMAN
Immunogen Region: 1-111
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-111 of human ASCC3 (NP_071374.1).
Immunogen Sequence: MALPRLTGALRSFSNVTKQD NYNEEVADLKIKRSKLHEQV LDLGLTWKKIIKFLNEKLEK SKMQSINEDLKDILHAAKQI EVNCPFQKRRLDGKEEDEKM SRASDRFRGLR
Tissue Specificity Ubiquitous.
Function ATPase involved both in DNA repair and rescue of stalled ribosomes. 3'-5' DNA helicase involved in repair of alkylated DNA: promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. Drives the splitting of stalled ribosomes that are ubiquitinated in a ZNF598-dependent manner, as part of the ribosome quality control trigger (RQT) complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation.
Protein Name Activating Signal Cointegrator 1 Complex Subunit 3
Asc-1 Complex Subunit P200
Asc1p200
Helicase - Atp Binding 1
Trip4 Complex Subunit P200
Database Links Reactome: R-HSA-112126
Cellular Localisation Nucleus
Nucleus Speckle
Cytoplasm
Cytosol
Colocalizes With Alkbh3 And Ascc2 In Nuclear Foci When Cells Have Been Exposed To Alkylating Agents That Cause Dna Damage
Alternative Antibody Names Anti-Activating Signal Cointegrator 1 Complex Subunit 3 antibody
Anti-Asc-1 Complex Subunit P200 antibody
Anti-Asc1p200 antibody
Anti-Helicase - Atp Binding 1 antibody
Anti-Trip4 Complex Subunit P200 antibody
Anti-ASCC3 antibody
Anti-HELIC1 antibody
Anti-RQT2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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