产品详情

  • 产品名称：SGLT1 Blocking Peptide peptide (STJ504920)

  • 产品型号：STJ504920-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
SGLT1 Blocking Peptide peptide (STJ504920)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: SGLT1 Blocking Peptide is synthetically produced from the 603-623 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: SLC5A1
Gene ID: 6523
Uniprot ID: SC5A1_HUMAN
Immunogen Region: 603-623
Immunogen: Synthetic peptide corresponding to amino acids 603-623 of Human SGLT1.
Tissue Specificity Expressed in intestine. Expressed in endometrial cells.
Post Translational Modifications N-glycosylation is not necessary for the cotransporter function.
Function Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump. Has a primary role in the transport of dietary monosaccharides from enterocytes to blood. Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2. Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis. Together with SGLT2, functions in reabsorption of D-glucose from glomerular filtrate, playing a nonredundant role in the S3 segment of the proximal tubules. Transports D-glucose into endometrial epithelial cells, controlling glycogen synthesis and nutritional support for the embryo as well as the decidual transformation of endometrium prior to conception. Acts as a water channel enabling passive water transport across the plasma membrane in response to the osmotic gradient created upon sugar and Na(+) uptake. Has high water conductivity, comparable to aquaporins, and therefore is expected to play an important role in transepithelial water permeability, especially in the small intestine.
Peptide Name Sodium/Glucose Cotransporter 1
Na(+/Glucose Cotransporter 1
High Affinity Sodium-Glucose Cotransporter
Solute Carrier Family 5 Member 1
Database Links Reactome: R-HSA-189200
Reactome: R-HSA-5656364
Reactome: R-HSA-8981373
Cellular Localisation Apical Cell Membrane
Multi-Pass Membrane Protein
Alternative Peptide Names Sodium/Glucose Cotransporter 1 protein
Na(+/Glucose Cotransporter 1 protein
High Affinity Sodium-Glucose Cotransporter protein
Solute Carrier Family 5 Member 1 protein
SLC5A1 protein
NAGT protein
SGLT1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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