产品详情

  • 产品名称：Human CNR2 (Cannabinoid Receptor 2, Macrophage) Sandwich ELISA Kit Ready-To-Use (STJE0014387)

  • 产品型号：STJE0014387
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human CNR2 (Cannabinoid Receptor 2, Macrophage) Sandwich ELISA Kit Ready-To-Use (STJE0014387)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 24.5pg/mL
Detection Limit: 62.5-4000pg/mL
Short Description: This CNR2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: CNR2
Gene ID: 1269
Uniprot ID: CNR2_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5' UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes.
Post Translational Modifications Constitutively phosphorylated on Ser-352.phosphorylation increases cell internalization and desensitizes the receptor.
Function Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
Protein Name Cannabinoid Receptor 2
Cb-2
Cb2
Hcb2
Cx5
Database Links Reactome: R-HSA-373076
Reactome: R-HSA-418594
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Dendrite
Perikaryon
Localizes To Apical Dendrite Of Pyramidal Neurons
Alternative ELISA Names Cannabinoid Receptor 2 ELISA kit
Cb-2 ELISA kit
Cb2 ELISA kit
Hcb2 ELISA kit
Cx5 ELISA kit
CNR2 ELISA kit
CB2A ELISA kit
CB2B ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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