产品详情

  • 产品名称：ROCK1 Blocking Peptide for STJ502821 peptide (STJ504867)

  • 产品型号：STJ504867-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
ROCK1 Blocking Peptide for STJ502821 peptide (STJ504867)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: ROCK1 Blocking Peptide for STJ502821 is synthetically produced from the 850-900 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: ROCK1
Gene ID: 6093
Uniprot ID: ROCK1_HUMAN
Immunogen Region: 850-900
Specificity: This blocking peptide is recommended for use in combination with ROCK1 antibody, STJ502821
Immunogen: Synthetic peptide taken within amino acid region spanning 850-900 on human ROCK1 protein.
Tissue Specificity Detected in blood platelets.
Post Translational Modifications Autophosphorylated on serine and threonine residues. Cleaved by caspase-3 during apoptosis. This leads to constitutive activation of the kinase and membrane blebbing.
Function Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1. Promotes keratinocyte terminal differentiation. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles.
Peptide Name Rho-Associated Protein Kinase 1
Renal Carcinoma Antigen Ny-Ren-35
Rho-Associated - Coiled-Coil-Containing Protein Kinase 1
Rho-Associated - Coiled-Coil-Containing Protein Kinase I
Rock-I
P160 Rock-1
P160rock
Database Links Reactome: R-HSA-111465
Reactome: R-HSA-3928662
Reactome: R-HSA-3928663
Reactome: R-HSA-416482
Reactome: R-HSA-416572
Reactome: R-HSA-4420097
Reactome: R-HSA-5627117
Reactome: R-HSA-6798695
Reactome: R-HSA-8980692
Reactome: R-HSA-9013026
Reactome: R-HSA-9013106
Reactome: R-HSA-9013407
Reactome: R-HSA-9013422
Reactome: R-HSA-9679191
Reactome: R-HSA-9696264
Cellular Localisation Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Centriole
Golgi Apparatus Membrane
Peripheral Membrane Protein
Cell Projection
Bleb
Cell Membrane
Lamellipodsium
Ruffle
A Small Proportion Is Associated With Golgi Membranes
Associated With The Mother Centriole And An Intercentriolar Linker
Colocalizes With Itgb1bp1 And Itgb1 At The Cell Membrane Predominantly In Lamellipodsia And Membrane Ruffles
But Also In Retraction Fibers
Localizes At The Cell Membrane In An Itgb1bp1-Dependent Manner
Alternative Peptide Names Rho-Associated Protein Kinase 1 protein
Renal Carcinoma Antigen Ny-Ren-35 protein
Rho-Associated - Coiled-Coil-Containing Protein Kinase 1 protein
Rho-Associated - Coiled-Coil-Containing Protein Kinase I protein
Rock-I protein
P160 Rock-1 protein
P160rock protein
ROCK1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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