产品详情

  • 产品名称：Mouse CD4 protein (Recombinant) (C-His) (STJP002472)

  • 产品型号：STJP002472-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Mouse CD4 protein (Recombinant) (C-His) (STJP002472)
详情介绍：
Host: HEK293 cells
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse CD4-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Cd4
Gene ID: 12504
Uniprot ID: CD4_MOUSE
Immunogen Region: Lys27-Thr394
Immunogen: Recombinant Mouse CD4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys27-Thr394) of mouse CD4 (Accession #NP_038516.1) fused with a 6×His tag at the C-terminus.
Post Translational Modifications Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts. Phosphorylated by PKC.phosphorylation plays an important role for CD4 internalization.
Function Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
Protein Name T-Cell Surface Glycoprotein Cd4
T-Cell Differentiation Antigen L3t4
T-Cell Surface Antigen T4/Leu-3
Cd Antigen Cd4
Database Links Reactome: R-MMU-1462054
Reactome: -MMU-202424
Reactome: -MMU-202427
Reactome: -MMU-202430
Reactome: -MMU-202433
Reactome: -MMU-389948
Reactome: -MMU-449836
Reactome: -MMU-8856825
Reactome: -MMU-8856828
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names T-Cell Surface Glycoprotein Cd4 protein
T-Cell Differentiation Antigen L3t4 protein
T-Cell Surface Antigen T4/Leu-3 protein
Cd Antigen Cd4 protein
Cd4 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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