产品详情

  • 产品名称：Anti-ARC antibody (70-150 aa) (STJ192386)

  • 产品型号：STJ192386
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ARC antibody (70-150 aa) (STJ192386)
详情介绍：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Activity-regulated cytoskeleton-associated protein (70-150 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ARC
Gene ID: 23237
Uniprot ID: ARC_HUMAN
Immunogen Region: 70-150 aa
Specificity: ARC Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from the human protein at the amino acid range 70-150
Function Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses. Accumulates at weaker synapses, probably to prevent their undesired enhancement. This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material. Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory. Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1. In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation.
Protein Name Activity-Regulated Cytoskeleton-Associated Protein
Harc
Activity-Regulated Gene 3.1 Protein Homolog
Arc/Arg3.1
Arg3.1
Database Links Reactome: R-HSA-9031628
Cellular Localisation Extracellular Vesicle Membrane
Lipid-Anchor
Postsynaptic Cell Membrane
Synapse
Postsynaptic Density
Early Endosome Membrane
Cell Projection
Dendrite
Cytoplasm
Cytoskeleton
Cell Cortex
Dendritic Spine
Cytoplasmic Vesicle
Secretory Vesicle
Acrosome
Clathrin-Coated Vesicle Membrane
Forms Virion-Like Extracellular Vesicles That Are Released From Neurons
Enriched In Postsynaptic Density Of Dendritic Spines
Targeted To Inactive Synapses Following Interaction With Camk2b In The Kinase Inactive State
Accumulation At Weaker Synapses May Be Required To Prevent Their Undesired Enhancement
Associated With The Cell Cortex Of Neuronal Soma And Dendrites
Associated With The Sperm Tail
Alternative Antibody Names Anti-Activity-Regulated Cytoskeleton-Associated Protein antibody
Anti-Harc antibody
Anti-Activity-Regulated Gene 3.1 Protein Homolog antibody
Anti-Arc/Arg3.1 antibody
Anti-Arg3.1 antibody
Anti-ARC antibody
Anti-KIAA0278 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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