产品详情

  • 产品名称：Anti-ALDH1A1 antibody (441-491) {Biotin} (STJ500064)

  • 产品型号：STJ500064-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ALDH1A1 antibody (441-491) {Biotin} (STJ500064)
详情介绍：
Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ALDH1A1 (441-491) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5 µg/µl
Dilution Range: WB: 1:2, 500-1:5, 000
ELISA: 1:50, 000
IP: 1:200
IHC: 1:50-1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Aldh1a1
Gene ID: 24188
Uniprot ID: AL1A1_RAT
Immunogen Region: 441-491
Immunogen: Synthetic peptide taken within amino acid region 441-491 on rat retinal dehydrogenase 1 protein.
Tissue Specificity Strongly expressed in kidney, lung, testis, intestine, stomach, and trachea, but weakly in the liver.
Post Translational Modifications The N-terminus is blocked most probably by acetylation.
Function Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid. Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid. This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic. Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification. Functions also downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins. Has also an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosesynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission.
Protein Name Aldehyde Dehydrogenase 1a1
3-Deoxyglucosone Dehydrogenase
Aldh-E1
Alhdii
Aldehyde Dehydrogenase Family 1 Member A1
Aldehyde Dehydrogenase - Cytosolic
Retinal Dehydrogenase 1
Raldh 1
Raldh1
Database Links Reactome: R-RNO-5365859
Reactome: -RNO-70350
Reactome: -RNO-71384
Cellular Localisation Cytoplasm
Cytosol
Cell Projection
Axon
Alternative Antibody Names Anti-Aldehyde Dehydrogenase 1a1 antibody
Anti-3-Deoxyglucosone Dehydrogenase antibody
Anti-Aldh-E1 antibody
Anti-Alhdii antibody
Anti-Aldehyde Dehydrogenase Family 1 Member A1 antibody
Anti-Aldehyde Dehydrogenase - Cytosolic antibody
Anti-Retinal Dehydrogenase 1 antibody
Anti-Raldh 1 antibody
Anti-Raldh1 antibody
Anti-Aldh1a1 antibody
Anti-Aldh antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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