产品详情

  • 产品名称：Anti-Aldehyde Reductase antibody (C-Term) (STJ70216)

  • 产品型号：STJ70216-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-Aldehyde Reductase antibody (C-Term) (STJ70216)
详情介绍：
Host: Goat
Applications: Pep-ELISA/WB/IHC
Reactivity: Human/Mouse/Rat/Dog/Pig/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-Aldehyde Reductase (C-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-0.1-0.3µg/ml
IHC-5µg/ml
ELISA-antibody detection limit dilution 1:16000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: AKR1A1
Gene ID: 10327
Uniprot ID: AK1A1_HUMAN
Immunogen Region: C-Term
Accession Number: NP_006057.1; NP_697021.1
Specificity: Both reported variants (NP_006057.1and NP_697021.1) represent identical protein
Immunogen Sequence: DAGHPLYPFNDPY
Function Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde. Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic. Involved also in the detoxification of lipid-derived aldehydes like acrolein. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). Displays no reductase activity towards retinoids.
Protein Name Aldo-Keto Reductase Family 1 Member A1
Alcohol Dehydrogenase Nadp(+
Aldehyde Reductase
Glucuronate Reductase
Glucuronolactone Reductase
Database Links Reactome: R-HSA-156590
Reactome: R-HSA-5661270
Cellular Localisation Cytoplasm
Cytosol
Apical Cell Membrane
Alternative Antibody Names Anti-Aldo-Keto Reductase Family 1 Member A1 antibody
Anti-Alcohol Dehydrogenase Nadp(+ antibody
Anti-Aldehyde Reductase antibody
Anti-Glucuronate Reductase antibody
Anti-Glucuronolactone Reductase antibody
Anti-AKR1A1 antibody
Anti-ALDR1 antibody
Anti-ALR antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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