产品详情

  • 产品名称：Human CCKBR (Cholecystokinin B Receptor) Sandwich ELISA Kit Ready-To-Use (STJE0014133)

  • 产品型号：STJE0014133
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human CCKBR (Cholecystokinin B Receptor) Sandwich ELISA Kit Ready-To-Use (STJE0014133)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.052ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This CCKBR Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: CCKBR
Gene ID: 887
Uniprot ID: GASR_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC-28 cell lines, not expressed in GLC-19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo.
Post Translational Modifications
Function Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.
Protein Name Gastrin/Cholecystokinin Type B Receptor
Cck-B Receptor
Cck-Br
Cholecystokinin-2 Receptor
Cck2-R
Database Links Reactome: R-HSA-375276
Reactome: R-HSA-416476
Reactome: R-HSA-881907
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative ELISA Names Gastrin/Cholecystokinin Type B Receptor ELISA kit
Cck-B Receptor ELISA kit
Cck-Br ELISA kit
Cholecystokinin-2 Receptor ELISA kit
Cck2-R ELISA kit
CCKBR ELISA kit
CCKRB ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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