产品详情

  • 产品名称：Anti-ANGPT1 antibody (161-293) (STJ117220)

  • 产品型号：STJ117220
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ANGPT1 antibody (161-293) (STJ117220)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ANGPT1 (161-293) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ANGPT1
Gene ID: 284
Uniprot ID: ANGP1_HUMAN
Immunogen Region: 161-293
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 161-293 of human ANGPT1 (NP_001186788.1).
Immunogen Sequence: IQLLENSLSTYKLEKQLLQQ TNEILKIHEKNSLLEHKILE MEGKHKEELDTLKEEKENLQ GLVTRQTYIIQELEKQLNRA TTNNSVLQKQQLELMDTVHN LVNLCTKEVLLKGGKREEEK PFRDCADVYQAGF
Post Translational Modifications Glycosylated.
Function Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.
Protein Name Angiopoietin-1
Ang-1
Database Links Reactome: R-HSA-210993
Reactome: R-HSA-5673001
Cellular Localisation Secreted
Alternative Antibody Names Anti-Angiopoietin-1 antibody
Anti-Ang-1 antibody
Anti-ANGPT1 antibody
Anti-KIAA0003 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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