产品详情

  • 产品名称：Human ATP6AP2 (ATPase, H+ Transporting, Lysosomal Accessory Protein 2) Sandwich ELISA Kit (STJE0007396)

  • 产品型号：STJE0007396
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human ATP6AP2 (ATPase, H+ Transporting, Lysosomal Accessory Protein 2) Sandwich ELISA Kit (STJE0007396)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.112ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This ATP6AP2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: ATP6AP2
Gene ID: 10159
Uniprot ID: RENR_HUMAN
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Expressed in brain, heart, placenta, liver, kidney and pancreas. Barely detectable in lung and skeletal muscles. In the kidney cortex it is restricted to the mesangium of glomeruli. In the coronary and kidney artery it is expressed in the subendothelium, associated to smooth muscles where it colocalizes with REN. Expressed in vascular structures and by syncytiotrophoblast cells in the mature fetal placenta.
Post Translational Modifications Phosphorylated. Proteolytically cleaved by a furin-like convertase in the trans-Golgi network to generate N- and C-terminal fragments.
Function Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission.
Protein Name Renin Receptor
Atpase H(+-Transporting Lysosomal Accessory Protein 2
Atpase H(+-Transporting Lysosomal-Interacting Protein 2
Er-Localized Type I Transmembrane Adapter
Embryonic Liver Differentiation Factor 10
N14f
Renin/Prorenin Receptor
Vacuolar Atp Synthase Membrane Sector-Associated Protein M8-9
Atp6m8-9
V-Atpase M8.9 Subunit Cleaved Into - Renin Receptor N-Terminal Fragment - Renin Receptor C-Terminal Fragment
Database Links Reactome: R-HSA-2022377
Reactome: R-HSA-6798695
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type I Membrane Protein
Lysosome Membrane
Cytoplasmic Vesicle
Autophagosome Membrane
Cell Projection
Dendritic Spine Membrane
Axon
Endosome Membrane
Clathrin-Coated Vesicle Membrane
Secretory Vesicle
Synaptic Vesicle Membrane
Alternative ELISA Names Renin Receptor ELISA kit
Atpase H(+-Transporting Lysosomal Accessory Protein 2 ELISA kit
Atpase H(+-Transporting Lysosomal-Interacting Protein 2 ELISA kit
Er-Localized Type I Transmembrane Adapter ELISA kit
Embryonic Liver Differentiation Factor 10 ELISA kit
N14f ELISA kit
Renin/Prorenin Receptor ELISA kit
Vacuolar Atp Synthase Membrane Sector-Associated Protein M8-9 ELISA kit
Atp6m8-9 ELISA kit
V-Atpase M8.9 Subunit Cleaved Into - Renin Receptor N-Terminal Fragment - Renin Receptor C-Terminal Fragment ELISA kit
ATP6AP2 ELISA kit
ATP6IP2 ELISA kit
CAPER ELISA kit
ELDF10 ELISA kit
HT028 ELISA kit
MSTP009 ELISA kit
PSEC0072 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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