产品详情

  • 产品名称：Anti-AGTR1/AT1 antibody (Internal) (STJ71011)

  • 产品型号：STJ71011-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-AGTR1/AT1 antibody (Internal) (STJ71011)
详情介绍：
Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-AGTR1/AT1 (Internal) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: ELISA-antibody detection limit dilution 1:32000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: AGTR1
Gene ID: 185
Uniprot ID: AGTR1_HUMAN
Immunogen Region: Internal
Accession Number: NP_000676.1; NP_004826.2; NP_033611.1; NP_114038.1; NP_114438.1
Specificity: All reported variants represent identical protein (NP_000676.1, NP_004826.2, NP_033611.1, NP_114038.1 and NP_114438.1).
Immunogen Sequence: EIQKNKPRNDDIFK
Post Translational Modifications C-terminal Ser or Thr residues may be phosphorylated.
Function Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C. (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis.
Protein Name Type-1 Angiotensin Ii Receptor
At1ar
At1br
Angiotensin Ii Type-1 Receptor
At1 Receptor
Database Links Reactome: R-HSA-375276
Reactome: R-HSA-416476
Reactome: R-HSA-8856825
Reactome: R-HSA-8856828
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Type-1 Angiotensin Ii Receptor antibody
Anti-At1ar antibody
Anti-At1br antibody
Anti-Angiotensin Ii Type-1 Receptor antibody
Anti-At1 Receptor antibody
Anti-AGTR1 antibody
Anti-AGTR1A antibody
Anti-AGTR1B antibody
Anti-AT2R1 antibody
Anti-AT2R1B antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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