产品详情

  • 产品名称：Human R-spondin-1 protein (Active Recombinant) (C-His) (STJP000847)

  • 产品型号：STJP000847
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human R-spondin-1 protein (Active Recombinant) (C-His) (STJP000847)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Active Recombinant-Human R-spondin-1-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its ability to enhance Cyclin D1 expression in HCT116 human colon adenocarcinoma cells.0.1-10ng/mL of Recombinant Human RSPO1 can effectively enhance Cyclin D1 expression.2. The intestinal crypts of mice were cultured in organoid culture
Gene Symbol: RSPO1
Gene ID: 284654
Uniprot ID: RSPO1_HUMAN
Immunogen Region: Arg31-Ala263
Immunogen: Active Recombinant Human R-spondin-1 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Arg31-Ala263) of human R-Spondin1 (Accession #NP_001033722.1) fused with a 6×His tag at the C-terminus.
Tissue Specificity Abundantly expressed in adrenal glands, ovary, testis, thyroid and trachea but not in bone marrow, spinal cord, stomach, leukocytes colon, small intestine, prostate, thymus and spleen.
Function Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1.
Protein Name R-Spondin-1
Roof Plate-Specific Spondin-1
Hrspo1
Database Links Reactome: R-HSA-4641263
Cellular Localisation Secreted
Nucleus
Seems To Mainly Localize To Nucleoli
Alternative Protein Names R-Spondin-1 protein
Roof Plate-Specific Spondin-1 protein
Hrspo1 protein
RSPO1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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