产品详情

  • 产品名称：Human Platelet Derived Growth Factor-BB protein (Recombinant) (STJP000308)

  • 产品型号：STJP000308
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human Platelet Derived Growth Factor-BB protein (Recombinant) (STJP000308)
详情介绍：
Host: S.cerevisiae
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Platelet Derived Growth Factor-BB-protein was developed from s.cerevisiae. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilised from 0.2 Mu m filtered.02M acetic acid solution pH.5.
Dilution Range: Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers.
Storage Instruction: Can be stored in working aliquots at°C-°C C for one month, or at-20°C C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. NA
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than.1 ng/µg (1EU/µg). NA
Immunoreactivity: The ED (50) was determined by the dose-dependent proliferation of Balb/cT3 cells.The expected ED50 for this effect is 1 ng/ml, corresponding to 1x10^6 IU/mg. NA
Gene Symbol: PDGFB
Gene ID: 5155
Uniprot ID: PDGFB_HUMAN
Immunogen Region: Mature chain
Immunogen: Optimized DNA sequence encoding Human PDGF-BB mature chain was expressed in Saccharomyces cerevisiae. NA
Immunogen Sequence: MNRCWALFLS LCCYLRLVSA EGDPIPEELY EMLSDHSIRS FDDLQRLLHG DPGEEDGAEL DLNMTRSHSG GELESLARGR RSLGSLTIAE PAMIAECKTR TEVFEISRRL IDRTNANFLV WPPCVEVQRC SGCCNNRNVQ CRPTQVQLRP VQVRKIEIVR KKPIFKKATV TLEDHLACKC ETVAAARPVT RSPGGSQEQR AKTPQTRVTI RTVRVRRPPK GKHRKFKH
Tissue Specificity Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung.
Function Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA.
Protein Name Platelet-Derived Growth Factor Subunit B
Pdgf Subunit B
Pdgf-2
Platelet-Derived Growth Factor B Chain
Platelet-Derived Growth Factor Beta Polypeptide
Proto-Oncogene C-Sis
Becaplermin
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-1257604
Reactome: R-HSA-186763
Reactome: R-HSA-186797
Reactome: R-HSA-2219530
Reactome: R-HSA-3000171
Reactome: R-HSA-5673001
Reactome: R-HSA-6811558
Cellular Localisation Secreted
Released By Platelets Upon Wounding
Alternative Protein Names Platelet-Derived Growth Factor Subunit B protein
Pdgf Subunit B protein
Pdgf-2 protein
Platelet-Derived Growth Factor B Chain protein
Platelet-Derived Growth Factor Beta Polypeptide protein
Proto-Oncogene C-Sis protein
Becaplermin protein
PDGFB protein
PDGF2 protein
SIS protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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