产品详情

  • 产品名称：LAMP1 Blocking Peptide for STJ501568 peptide (STJ504288)

  • 产品型号：STJ504288-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
LAMP1 Blocking Peptide for STJ501568 peptide (STJ504288)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: LAMP1 Blocking Peptide for STJ501568 is synthetically produced from the 300-350 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: LAMP1
Gene ID: 3916
Uniprot ID: LAMP1_HUMAN
Immunogen Region: 300-350
Specificity: This blocking peptide is recommended for use in combination with LAMP1 antibody, STJ501568
Immunogen: Synthetic peptide taken within amino acid region 300-350 on human LAMP1 protein.
Post Translational Modifications O- and N-glycosylated.some of the 18 N-linked glycans are polylactosaminoglycans. (Microbial infection) The glycosylation of Asn-76 is essential for Lassa virus entry into cells.
Function Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis. Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity. Also plays an important role in NK-cells cytotoxicity. Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule. In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content. Presents carbohydrate ligands to selectins. (Microbial infection) Acts as a receptor for Lassa virus glycoprotein. Promotes also fusion of the virus with host membrane in less acidic endosomes. (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F.
Peptide Name Lysosome-Associated Membrane Glycoprotein 1
Lamp-1
Lysosome-Associated Membrane Protein 1
Cd107 Antigen-Like Family Member A
Cd Antigen Cd107a
Database Links Reactome: R-HSA-6798695
Cellular Localisation Lysosome Membrane
Single-Pass Type I Membrane Protein
Endosome Membrane
Late Endosome Membrane
Cell Membrane
Cytolytic Granule Membrane
This Protein Shuttles Between Lysosomes
Endosomes
And The Plasma Membrane
Colocalizes With Osbpl1a At The Late Endosome
Alternative Peptide Names Lysosome-Associated Membrane Glycoprotein 1 protein
Lamp-1 protein
Lysosome-Associated Membrane Protein 1 protein
Cd107 Antigen-Like Family Member A protein
Cd Antigen Cd107a protein
LAMP1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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