产品详情

  • 产品名称：Human CAMK2a (Calcium/Calmodulin Dependent Protein Kinase II Alpha) Sandwich ELISA Kit (STJE0007656)

  • 产品型号：STJE0007656
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human CAMK2a (Calcium/Calmodulin Dependent Protein Kinase II Alpha) Sandwich ELISA Kit (STJE0007656)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.064ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This CAMK2a Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: CAMK2A
Gene ID: 815
Uniprot ID: KCC2A_HUMAN
Sample Type: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity
Post Translational Modifications Autophosphorylation of Thr-286 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-286 locks the kinase into an activated state. Palmitoylated. Probably palmitoylated by ZDHHC3 and ZDHHC7.
Function Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission. Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity. Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway. In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway. Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity.
Protein Name Calcium/Calmodulin-Dependent Protein Kinase Type Ii Subunit Alpha
Cam Kinase Ii Subunit Alpha
Camk-Ii Subunit Alpha
Database Links Reactome: R-HSA-111932
Reactome: R-HSA-3371571
Reactome: R-HSA-399719
Reactome: R-HSA-4086398
Reactome: R-HSA-438066
Reactome: R-HSA-442982
Reactome: R-HSA-5576892
Reactome: R-HSA-5578775
Reactome: R-HSA-5673000
Reactome: R-HSA-5673001
Reactome: R-HSA-6802946
Reactome: R-HSA-6802952
Reactome: R-HSA-6802955
Reactome: R-HSA-877300
Reactome: R-HSA-9022692
Reactome: R-HSA-936837
Reactome: R-HSA-9609736
Reactome: R-HSA-9617324
Reactome: R-HSA-9620244
Reactome: R-HSA-9649948
Reactome: R-HSA-9656223
Cellular Localisation Synapse
Postsynaptic Density
Cell Projection
Dendritic Spine
Dendrite
Postsynaptic Lipid Rafts
Alternative ELISA Names Calcium/Calmodulin-Dependent Protein Kinase Type Ii Subunit Alpha ELISA kit
Cam Kinase Ii Subunit Alpha ELISA kit
Camk-Ii Subunit Alpha ELISA kit
CAMK2A ELISA kit
CAMKA ELISA kit
KIAA0968 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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