产品详情

  • 产品名称：Anti-APH1A antibody (C-Term) (STJ116870)

  • 产品型号：STJ116870
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-APH1A antibody (C-Term) (STJ116870)
详情介绍：
Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-APH1A (C-Term) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IF/ICC 1:50-1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: APH1A
Gene ID: 51107
Uniprot ID: APH1A_HUMAN
Immunogen Region: C-Term
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human APH1A (NP_001071096.1).
Immunogen Sequence: TSGLTFLNPWYEASLLPIYA VTVSMGLWAFITAGGSLRSI QRSLLCRRQEDSRVMVYSAL RIPPED
Tissue Specificity Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. Isoform 1 and isoform 2 are nearly expressed at the same level.
Function Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Required for normal gamma-secretase assembly. The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable).
Protein Name Gamma-Secretase Subunit Aph-1a
Aph-1a
Aph-1alpha
Presenilin-Stabilization Factor
Database Links Reactome: R-HSA-1251985
Reactome: R-HSA-193692
Reactome: R-HSA-205043
Reactome: R-HSA-2122948
Reactome: R-HSA-2644606
Reactome: R-HSA-2894862
Reactome: R-HSA-2979096
Reactome: R-HSA-3928665
Reactome: R-HSA-9013507
Reactome: R-HSA-9013700
Reactome: R-HSA-9017802
Reactome: R-HSA-977225
Cellular Localisation Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Golgi Apparatus
Golgi Stack Membrane
Predominantly Located In The Endoplasmic Reticulum And In The Cis-Golgi
Alternative Antibody Names Anti-Gamma-Secretase Subunit Aph-1a antibody
Anti-Aph-1a antibody
Anti-Aph-1alpha antibody
Anti-Presenilin-Stabilization Factor antibody
Anti-APH1A antibody
Anti-PSF antibody
Anti-CGI-78 antibody
Anti-UNQ579 antibody
Anti-PRO1141 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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