产品详情

  • 产品名称：Human TNF-alpha protein (Recombinant) {Biotin} (STJP000187)

  • 产品型号：STJP000187
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human TNF-alpha protein (Recombinant) {Biotin} (STJP000187)
详情介绍：
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation: Biotin
Gene Symbol: TNF
Gene ID: 7124
Uniprot ID: TNFA_HUMAN
Function Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Up-regulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6. Promotes osteoclastogenesis and therefore mediates bone resorption. The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
Protein Name Tumor Necrosis Factor
Cachectin
Tnf-Alpha
Tumor Necrosis Factor Ligand Superfamily Member 2
Tnf-A Cleaved Into - Tumor Necrosis Factor - Membrane Form
N-Terminal Fragment
Ntf - Intracellular Domain 1
Icd1 - Intracellular Domain 2
Icd2 - C-Domain 1 - C-Domain 2 - Tumor Necrosis Factor - Soluble Form
Database Links Reactome: R-HSA-381340
Reactome: R-HSA-5357786
Reactome: R-HSA-5357905
Reactome: R-HSA-5357956
Reactome: R-HSA-5626978
Reactome: R-HSA-5668541
Reactome: R-HSA-6783783
Reactome: R-HSA-6785807
Reactome: R-HSA-75893
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Tumor Necrosis Factor
Membrane Form: Membrane
Soluble Form: Secreted
C-Domain 1: Secreted
C-Domain 2: Secreted
Alternative Protein Names Tumor Necrosis Factor protein
Cachectin protein
Tnf-Alpha protein
Tumor Necrosis Factor Ligand Superfamily Member 2 protein
Tnf-A Cleaved Into - Tumor Necrosis Factor - Membrane Form protein
N-Terminal Fragment protein
Ntf - Intracellular Domain 1 protein
Icd1 - Intracellular Domain 2 protein
Icd2 - C-Domain 1 - C-Domain 2 - Tumor Necrosis Factor - Soluble Form protein
TNF protein
TNFA protein
TNFSF2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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