产品详情

  • 产品名称：PDE3A Blocking Peptide peptide (Phospho) (STJ504775)

  • 产品型号：STJ504775-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
PDE3A Blocking Peptide peptide (Phospho) (STJ504775)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Phospho-PDE3A Blocking Peptide is synthetically produced from the 200-300 sequence and is suitable for use in western blot applications.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Pde3a
Gene ID: 54611
Uniprot ID: PDE3A_MOUSE
Immunogen Region: 200-300
Immunogen: Synthetic peptide taken within amino acid region 200-300 on mouse PDE3A protein. Phosphorylated Serine 290 & 292 residues.
Function Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has also activity toward cUMP. Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling.
Peptide Name Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3a
Cyclic Gmp-Inhibited Phosphodiesterase A
Cgi-Pde A
Database Links Reactome: R-MMU-418555
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Cytoplasm
Cytosol
Alternative Peptide Names Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3a protein
Cyclic Gmp-Inhibited Phosphodiesterase A protein
Cgi-Pde A protein
Pde3a protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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