产品详情

  • 产品名称：Human BIN1 (Bridging Integrator 1) Sandwich ELISA Kit (STJE0007477)

  • 产品型号：STJE0007477
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human BIN1 (Bridging Integrator 1) Sandwich ELISA Kit (STJE0007477)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.51pg/mL
Detection Limit: 1.56-100pg/mL
Short Description: This BIN1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: BIN1
Gene ID: 274
Uniprot ID: BIN1_HUMAN
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Ubiquitous. Highest expression in the brain and muscle. Expressed in oligodendrocytes. Isoform IIA is expressed only in the brain, where it is detected in the gray matter, but not in the white matter. Isoform BIN1 is widely expressed with highest expression in skeletal muscle.
Post Translational Modifications Phosphorylated by protein kinase C.
Function Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Is a negative regulator of endocytosis. Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production. In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates. May be involved in the regulation of MYC activity and the control cell proliferation. Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro.
Protein Name Myc Box-Dependent-Interacting Protein 1
Amphiphysin Ii
Amphiphysin-Like Protein
Box-Dependent Myc-Interacting Protein 1
Bridging Integrator 1
Database Links Reactome: R-HSA-8856828
Cellular Localisation Isoform Bin1: Nucleus
Cytoplasm
Endosome
Cell Membrane
Sarcolemma
T-Tubule
Isoform Iia: Cytoplasm
Alternative ELISA Names Myc Box-Dependent-Interacting Protein 1 ELISA kit
Amphiphysin Ii ELISA kit
Amphiphysin-Like Protein ELISA kit
Box-Dependent Myc-Interacting Protein 1 ELISA kit
Bridging Integrator 1 ELISA kit
BIN1 ELISA kit
AMPHL ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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