产品详情

  • 产品名称：Anti-ANG antibody (25-147) (STJ115426)

  • 产品型号：STJ115426
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ANG antibody (25-147) (STJ115426)
详情介绍：
Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ANG (25-147) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ANG
Gene ID: 283
Uniprot ID: ANGI_HUMAN
Immunogen Region: 25-147
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 25-147 of human ANG (NP_001136.1).
Immunogen Sequence: QDNSRYTHFLTQHYDAKPQG RDDRYCESIMRRRGLTSPCK DINTFIHGNKRSIKAICENK NGNPHRENLRISKSSFQVTT CKLHGGSPWPPCQYRATAGF RNVVVACENGLPVHLDQSIF RRP
Tissue Specificity Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons.
Function Ribonuclease that cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Binds to actin on the surface of endothelial cells.once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
Protein Name Angiogenin
Ribonuclease 5
Rnase 5
Database Links Reactome: R-HSA-418990
Reactome: R-HSA-9708296
Cellular Localisation Cytoplasmic Vesicle
Secretory Vesicle Lumen
Secreted
Nucleus
Nucleolus
Rapidly Endocytosed By Target Cells And Translocated To The Nucleus Where It Accumulates In The Nucleolus And Binds To Dna
Alternative Antibody Names Anti-Angiogenin antibody
Anti-Ribonuclease 5 antibody
Anti-Rnase 5 antibody
Anti-ANG antibody
Anti-RNASE5 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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