产品详情
简单介绍:
Human Serpin D1/Heparin cofactor 2 protein (Recombinant) (C-His) (STJP001220)
详情介绍:
Host: | HEK293 cells |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Recombinant-Human Serpin D1/Heparin cofactor 2-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
Formulation: | Lyophilized from a 0.22 Mu m filtered solution of 50mM TRIS, 150mM NaCl, pH7.5. Contact us for customized product form or formulation. |
Immunoreactivity: | Measured by its ability to inhibit Recombinant Human Coagulation Factor II/Thrombin cleavage of a fluorogenic peptide substrate Boc-VPR-AMC. The IC50 value is |
Gene Symbol: | SERPIND1 |
Gene ID: | 3053 |
Uniprot ID: | HEP2_HUMAN |
Immunogen: | Recombinant Human Serpin D1/Heparin cofactor 2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly20-Ser499) of human Serpin D1/Heparin Cofactor II (Accession #NP_000176.2.) fused with a 6×His tag |
Post Translational Modifications | Phosphorylated by FAM20C in the extracellular medium. |
Function | Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils. |
Protein Name | Heparin Cofactor 2 Heparin Cofactor Ii Hc-Ii Protease Inhibitor Leuserpin-2 Hls2 Serpin D1 |
Database Links | Reactome: R-HSA-140837 Reactome: R-HSA-140875 Reactome: R-HSA-381426 Reactome: R-HSA-8957275 |
Alternative Protein Names | Heparin Cofactor 2 protein Heparin Cofactor Ii protein Hc-Ii protein Protease Inhibitor Leuserpin-2 protein Hls2 protein Serpin D1 protein SERPIND1 protein HCF2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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