产品详情

  • 产品名称：NTH1 Positive Control peptide (STJ504492)

  • 产品型号：STJ504492-5
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
NTH1 Positive Control peptide (STJ504492)
详情介绍：
Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: NTH1 Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: NTHL1
Gene ID: 4913
Uniprot ID: NTH_HUMAN
Tissue Specificity Widely expressed with highest levels in heart and lowest levels in lung and liver.
Post Translational Modifications Ubiquitinated by TRIM26.leading to proteasomal degradation.
Function Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.
Peptide Name Endonuclease Iii-Like Protein 1
Hnth1
Bifunctional Dna N-Glycosylase/Dna-(Apurinic Or Apyrimidinic Site Lyase
Dna Glycosylase/Ap Lyase
Database Links Reactome: R-HSA-110328
Reactome: R-HSA-110329
Reactome: R-HSA-110357
Reactome: R-HSA-9630221
Reactome: R-HSA-9630222
Cellular Localisation Nucleus
Mitochondrion
Alternative Peptide Names Endonuclease Iii-Like Protein 1 protein
Hnth1 protein
Bifunctional Dna N-Glycosylase/Dna-(Apurinic Or Apyrimidinic Site Lyase protein
Dna Glycosylase/Ap Lyase protein
NTHL1 protein
NTH1 protein
OCTS3 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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