产品详情

  • 产品名称：Human ATP4a (ATPase, H+/K+ Exchanging Alpha Polypeptide) Sandwich ELISA Kit (STJE0007390)

  • 产品型号：STJE0007390
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human ATP4a (ATPase, H+/K+ Exchanging Alpha Polypeptide) Sandwich ELISA Kit (STJE0007390)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.055ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This ATP4a Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: ATP4A
Gene ID: 495
Uniprot ID: ATP4A_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Expressed in gastric parietal cells (at protein level).
Post Translational Modifications
Function The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell. Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1. Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state.
Protein Name Potassium-Transporting Atpase Alpha Chain 1
Gastric H(+/K(+ Atpase Subunit Alpha
Proton Pump
Database Links Reactome: R-HSA-936837
Cellular Localisation Apical Cell Membrane
Multi-Pass Membrane Protein
Localized In The Apical Canalicular Membrane Of Parietal Cells
Alternative ELISA Names Potassium-Transporting Atpase Alpha Chain 1 ELISA kit
Gastric H(+/K(+ Atpase Subunit Alpha ELISA kit
Proton Pump ELISA kit
ATP4A ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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