产品详情

  • 产品名称：Human ATP2B2 (ATPase, Ca++ Transporting, Plasma Membrane 2) Sandwich ELISA Kit Ready-To-Use (STJE0013762)

  • 产品型号：STJE0013762
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human ATP2B2 (ATPase, Ca++ Transporting, Plasma Membrane 2) Sandwich ELISA Kit Ready-To-Use (STJE0013762)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.112ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This ATP2B2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: ATP2B2
Gene ID: 491
Uniprot ID: AT2B2_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Mainly expressed in brain cortex. Found in low levels in skeletal muscle, heart muscle, stomach, liver, kidney and lung. Isoforms containing segment B are found in brain cortex and at low levels in other tissues. Isoforms containing segments X and W are found at low levels in all tissues. Isoforms containing segment A and segment Z are found at low levels in skeletal muscle and heart muscle.
Post Translational Modifications
Function ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems. Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment. Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning. Plays an essential role in hearing and balance. In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia. In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels. In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk.
Protein Name Plasma Membrane Calcium-Transporting Atpase 2
Pmca2
Plasma Membrane Calcium Atpase Isoform 2
Plasma Membrane Calcium Pump Isoform 2
Database Links Reactome: R-HSA-418359
Reactome: R-HSA-5578775
Reactome: R-HSA-936837
Reactome: R-HSA-9662360 Q01814-2
Reactome: R-HSA-9662361 Q01814-2
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Synapse
Isoform Wa: Apical Cell Membrane
Basolateral Cell Membrane
Isoform Wb: Apical Cell Membrane
Isoform Xb: Basolateral Cell Membrane
Isoform Za: Basolateral Cell Membrane
Isoform Zb: Basolateral Cell Membrane
Alternative ELISA Names Plasma Membrane Calcium-Transporting Atpase 2 ELISA kit
Pmca2 ELISA kit
Plasma Membrane Calcium Atpase Isoform 2 ELISA kit
Plasma Membrane Calcium Pump Isoform 2 ELISA kit
ATP2B2 ELISA kit
PMCA2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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