产品详情

  • 产品名称：Human NovH/CCN3 (N97K) protein (Recombinant) (C-His) (STJP001202)

  • 产品型号：STJP001202
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human NovH/CCN3 (N97K) protein (Recombinant) (C-His) (STJP001202)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human NovH/CCN3 (N97K)-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Gene Symbol: CCN3
Gene ID: 4856
Uniprot ID: CCN3_HUMAN
Immunogen: Recombinant Human NovH/CCN3 (N97K) Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr32-Met357 (Asn97Lys) ) of human NOV/CCN3 (Accession #NP_002505.1) fused with a 6×His tag at the C-terminus.
Post Translational Modifications May be palmitoylated on Cys-244, which is important for extracellular secretion.
Function Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival. Acts by binding to integrins or membrane receptors such as NOTCH1. Essential regulator of hematopoietic stem and progenitor cell function. Inhibits myogenic differentiation through the activation of Notch-signaling pathway. Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling. Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival. Also plays a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts. Involved in bone regeneration as a negative regulator. Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification. Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion. Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway. Contributes to the control and coordination of inflammatory processes in atherosclerosis. Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement.
Protein Name Ccn Family Member 3
Cellular Communication Network Factor 3
Insulin-Like Growth Factor-Binding Protein 9
Ibp-9
Igf-Binding Protein 9
Igfbp-9
Nephro Blastoma-Overexpressed Gene Protein Homolog
Protein Nov Homolog
Novh
Cellular Localisation Secreted
Cytoplasm
Cell Junction
Gap Junction
Localizes At The Gap Junction In Presence Of Gja1
Alternative Protein Names Ccn Family Member 3 protein
Cellular Communication Network Factor 3 protein
Insulin-Like Growth Factor-Binding Protein 9 protein
Ibp-9 protein
Igf-Binding Protein 9 protein
Igfbp-9 protein
Nephro Blastoma-Overexpressed Gene Protein Homolog protein
Protein Nov Homolog protein
Novh protein
CCN3 protein
IGFBP9 protein
NOV protein
NOVH protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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