产品详情

  • 产品名称：Anti-ALPK1 antibody (340-500) (STJ11103266)

  • 产品型号：STJ11103266
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ALPK1 antibody (340-500) (STJ11103266)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ALPK1 (340-500) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ALPK1
Gene ID: 80216
Uniprot ID: ALPK1_HUMAN
Immunogen Region: 340-500
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 340-500 of human ALPK1 (NP_001095876.1).
Immunogen Sequence: RDDEPVTGKQELHSFVKAAF GLTTVHRRLHGETGTVHAAS QLCKEAMGKLYNFSTSSRSQ DREALSQEVMSVIAQVKEHL QVQSFSNVDDRSYVPESFEC RLDKLILHGQGDFQKILDTY SQHHTSVCEVFESDCGNNKN EQKDAKTGVCITALKTEIKN I
Tissue Specificity Highly expressed in liver. Expressed in the optic nerve and retinal pigmented epithelium. Lower expression is observed in the macula and extramacular retina.
Function Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity. Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria. ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering pro-inflammatory NF-kappa-B signaling. May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A. May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A. May play a role in ciliogenesis.
Protein Name Alpha-Protein Kinase 1
Chromosome 4 Kinase
Lymphocyte Alpha-Protein Kinase
Database Links Reactome: R-HSA-445989
Reactome: R-HSA-9645460
Cellular Localisation Cytoplasm
Cytosol
Cytoskeleton
Spindle Pole
Microtubule Organizing Center
Centrosome
Cell Projection
Cilium
Localized At The Base Of Primary Cilia
Alternative Antibody Names Anti-Alpha-Protein Kinase 1 antibody
Anti-Chromosome 4 Kinase antibody
Anti-Lymphocyte Alpha-Protein Kinase antibody
Anti-ALPK1 antibody
Anti-KIAA1527 antibody
Anti-LAK antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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