产品详情

  • 产品名称：MERTK Blocking Peptide peptide (Phospho) (STJ504753)

  • 产品型号：STJ504753-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
MERTK Blocking Peptide peptide (Phospho) (STJ504753)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Phospho-MERTK Blocking Peptide is synthetically produced from the 746-757 sequence and is suitable for use in western blot applications.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Mertk
Gene ID: 65037
Uniprot ID: MERTK_RAT
Immunogen Region: 746-757
Immunogen: Synthetic peptide corresponding to amino acids 746-757 of Human MERTK. Sequence: CKKIYpSGDYpYpRQG
Post Translational Modifications Autophosphorylated on Tyr-744, Tyr-748 and Tyr-749 in the activation loop allowing full activity. Autophosphorylated on Tyr-867 leading to recruitment of downstream partners of the signaling cascade such as PLCG2.
Function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Peptide Name Tyrosine-Protein Kinase Mer
Proto-Oncogene C-Mer
Receptor Tyrosine Kinase Mertk
Database Links Reactome: R-RNO-202733
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Peptide Names Tyrosine-Protein Kinase Mer protein
Proto-Oncogene C-Mer protein
Receptor Tyrosine Kinase Mertk protein
Mertk protein
Mer protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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