产品详情

  • 产品名称：Human Lipocalin-2 protein (Recombinant) (STJP000744)

  • 产品型号：STJP000744
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human Lipocalin-2 protein (Recombinant) (STJP000744)
详情介绍：
Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Lipocalin-2-protein was developed from hek293. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose.
Storage Instruction: Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA
Immunoreactivity: The activity was tested by the ability to bind Iron dihydroxybenzoic acid and was measured to be > 1.5uM. NA
Gene Symbol: LCN2
Gene ID: 3934
Uniprot ID: NGAL_HUMAN
Immunogen Region: GLN21-GLY198
Immunogen: Optimized DNA sequence encoding extracellular domain of Human Neutrophil gelatinase-associated lipocalin-NGAL (GLN21-GLY198 ) including a C-terminal His tag was expressed in HEK293 cells. NA
Tissue Specificity Detected in neutrophils (at protein level). Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Expressed in the medullary tubules of the kidney. Not found in the small intestine or peripheral blood leukocytes.
Function Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,3-dihydroxybenzoic acid (2,3-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity.limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin. Can also bind siderophores from M.tuberculosis.
Protein Name Neutrophil Gelatinase-Associated Lipocalin
Ngal
25 Kda Alpha-2-Microglobulin-Related Subunit Of Mmp-9
Lipocalin-2
Oncogene 24p3
Siderocalin
P25
Database Links Reactome: R-HSA-6785807
Reactome: R-HSA-6798695
Reactome: R-HSA-6799990
Reactome: R-HSA-917937
Cellular Localisation Secreted
Cytoplasmic Granule Lumen
Cytoplasmic Vesicle Lumen
Upon Binding To The Slc22a17 (24p3r) Receptor
It Is Internalized
Releases The Bound Iron In The Acidic Lumen Of Cytoplasmic Vesicles
Alternative Protein Names Neutrophil Gelatinase-Associated Lipocalin protein
Ngal protein
25 Kda Alpha-2-Microglobulin-Related Subunit Of Mmp-9 protein
Lipocalin-2 protein
Oncogene 24p3 protein
Siderocalin protein
P25 protein
LCN2 protein
HNL protein
NGAL protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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