产品详情

  • 产品名称：Anti-AKR1D1 antibody (1-326) (STJ111755)

  • 产品型号：STJ111755
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-AKR1D1 antibody (1-326) (STJ111755)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-AKR1D1 (1-326) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: AKR1D1
Gene ID: 6718
Uniprot ID: AK1D1_HUMAN
Immunogen Region: 1-326
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-326 of human AKR1D1 (NP_005980.1).
Immunogen Sequence: MDLSAASHRIPLSDGNSIPI IGLGTYSEPKSTPKGACATS VKVAIDTGYRHIDGAYIYQN EHEVGEAIREKIAEGKVRRE DIFYCGKLWATNHVPEMVRP TLERTLRVLQLDYVDLYIIE VPMAFKPGDEIYPRDENGKW LYHKSNLCATWEAMEACKDA GLVKSLGVSNFNRRQLELIL NKPGLKHKPVSNQVECHPYF TQPKLLKFCQQHDIVITAYS PLGTSRNPIWVNVSSPPLL
Tissue Specificity Highly expressed in liver. Expressed in testis and weakly in colon.
Function Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosesynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta-hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3-one).
Protein Name Aldo-Keto Reductase Family 1 Member D1
3-Oxo-5-Beta-Steroid 4-Dehydrogenase
Delta(4-3-Ketosteroid 5-Beta-Reductase
Delta(4-3-Oxosteroid 5-Beta-Reductase
Database Links Reactome: R-HSA-193368
Reactome: R-HSA-193775
Reactome: R-HSA-193807
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Aldo-Keto Reductase Family 1 Member D1 antibody
Anti-3-Oxo-5-Beta-Steroid 4-Dehydrogenase antibody
Anti-Delta(4-3-Ketosteroid 5-Beta-Reductase antibody
Anti-Delta(4-3-Oxosteroid 5-Beta-Reductase antibody
Anti-AKR1D1 antibody
Anti-SRD5B1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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