产品详情

  • 产品名称：Anti-AIMP2 antibody (STJA0004416)

  • 产品型号：STJA0004416
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-AIMP2 antibody (STJA0004416)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Rat
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Aminoacyl Trna Synthase Complex-Interacting Multifunctional Protein 2 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.
Purification: Affinity purification
Concentration: 2 mg/mL
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Gene Symbol: AIMP2
Gene ID: 7965
Uniprot ID: AIMP2_HUMAN
Immunogen: Recombinant Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 protein
Post Translational Modifications Phosphorylated on serine residues in response to UV irradiation. Ubiquitinated by PRKN, leading to its degradation by the proteasome. Mutant PRKN fails to ubiquitinate AIMP2 efficiently, allowing its accumulation which may contribute to neurodegeneration associated with Parkinson disease.
Function Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
Protein Name Aminoacyl Trna Synthase Complex-Interacting Multifunctional Protein 2
Multisynthase Complex Auxiliary Component P38
Protein Jtv-1
Database Links Reactome: R-HSA-2408522
Reactome: R-HSA-379716
Cellular Localisation Cytoplasm
Cytosol
Nucleus
Following Dna Damage
Dissociates From The Aminoacyl-Trna Synthase Complex And Translocates From The Cytoplasm To The Nucleus
Alternative Antibody Names Anti-Aminoacyl Trna Synthase Complex-Interacting Multifunctional Protein 2 antibody
Anti-Multisynthase Complex Auxiliary Component P38 antibody
Anti-Protein Jtv-1 antibody
Anti-AIMP2 antibody
Anti-JTV1 antibody
Anti-PRO0992 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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